Macroscopic nephrocalcinosis - the detection of calcium deposits on radiological imaging - can be divided into cortical and medullary forms.
Cortical nephrocalcinosis is quite rare, accounting for less than 3% of all cases of nephrocalcinosis (1).
Commonly cited causes include (1-3):
- Renal cortical necrosis
- Chronic glomerulonephritis
- Alport syndrome (Fig. 2-4)
The mechanisms of calcium deposition in cortical nephrocalcinosis are not well studied, if at all. Most cases are probably the result of dystrophic calcifications (i.e. due to local tissue abnormalities). Occasionally, disorders of calcium metabolism may also play a role (1).
- Wrong O. Nephrocalcinosis. In: Oxford textbook of clinical nephrology. 2nd ed. Cameron S, Davison AM, eds. Oxford: Oxford University Press; October 9, 1997.
- Schepens D, Verswijvel G, Kuypers D, Vanrenterghem Y. Renal cortical nephrocalcinosis. Nephrology Dialysis Transplantation. 2000;15(7):1080–1082. doi:10.1093/ndt/15.7.1080.
- Zagoria RJ. Genitourinary Radiology: The requisites. 2nd ed. United States: Elsevier Health Sciences; June 4, 2004.